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α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine.

ABSTRACT: As a drug carrier, polyrotaxane (PR) has been used for targeted delivery and sustained release of drugs, whereas silver sulfadiazine (SD-Ag) is an emerging antibiotic agent. PR was synthesized by the use of α-cyclodextrin (CD) and poly(ethylene glycol) (PEG), and a specific antibacterial material (PR-(SD-Ag)) was then prepared by loading SD-Ag onto PR with different mass ratios. The loading capacity and the encapsulation efficiency were 90% at a mass ratio of 1:1 of PR and SD-Ag. SD-Ag was released stably and slowly within 6 d in vitro, and its cumulative release reached more than 85%. The mechanism of PR loading SD-Ag might be that SD-Ag attached to the edge of α-CD through hydrogen bonding. PR-(SD-Ag) showed a higher light stability than SD-Ag and held excellent antibacterial properties against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus).

SUBMITTER: Liu S

PROVIDER: S-EPMC6415174 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine.

Liu Sa S Zhong Chunting C Wang Weiwei W Jia Yongguang Y Wang Lin L Ren Li L

Polymers 20180214 2

As a drug carrier, polyrotaxane (PR) has been used for targeted delivery and sustained release of drugs, whereas silver sulfadiazine (SD-Ag) is an emerging antibiotic agent. PR was synthesized by the use of α-cyclodextrin (CD) and poly(ethylene glycol) (PEG), and a specific antibacterial material (PR-(SD-Ag)) was then prepared by loading SD-Ag onto PR with different mass ratios. The loading capacity and the encapsulation efficiency were 90% at a mass ratio of 1:1 of PR and SD-Ag. SD-Ag was relea ...[more]

PMID: 30966226

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