Repeated clinical malaria episodes are associated with modification of the immune system in children.

ABSTRACT:

Background

There are over 200 million reported cases of malaria each year, and most children living in endemic areas will experience multiple episodes of clinical disease before puberty. We set out to understand how frequent clinical malaria, which elicits a strong inflammatory response, affects the immune system and whether these modifications are observable in the absence of detectable parasitaemia.

Methods

We used a multi-dimensional approach comprising whole blood transcriptomic, cellular and plasma cytokine analyses on a cohort of children living with endemic malaria, but uninfected at sampling, who had been under active surveillance for malaria for 8 years. Children were categorised into two groups depending on the cumulative number of episodes experienced: high (≥ 8)

SUBMITTER: Bediako Y 

PROVIDER: S-EPMC6415347 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature