Disability-Specific Atlases of Gray Matter Loss in Relapsing-Remitting Multiple Sclerosis.

ABSTRACT:

Importance

Multiple sclerosis (MS) is characterized by progressive gray matter (GM) atrophy that strongly correlates with clinical disability. However, whether localized GM atrophy correlates with specific disabilities in patients with MS remains unknown.

Objective

To understand the association between localized GM atrophy and clinical disability in a biology-driven analysis of MS.

Design, setting, and participants

In this cross-sectional study, magnetic resonance images were acquired from 133 women with relapsing-remitting MS and analyzed using voxel-based morphometry and volumetry. A regression analysis was used to determine whether voxelwise GM atrophy was associated with specific clinical deficits. Data were collected from June 28, 2007, to January 9, 2014.

Mai

SUBMITTER: MacKenzie-Graham A 

PROVIDER: S-EPMC6415681 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature