Role of Germline Genetics in Identifying Survivors at Risk for Adverse Effects of Cancer Treatment.

ABSTRACT: The growing population of cancer survivors often faces adverse effects of treatment, which have a substantial impact on morbidity and mortality. Although certain adverse effects are thought to have a significant heritable component, much work remains to be done to understand the role of germline genetic factors in the development of treatment-related toxicities. In this article, we review current understanding of genetic susceptibility to a range of adverse outcomes among cancer survivors (e.g., fibrosis, urinary and rectal toxicities, ototoxicity, chemotherapy-induced peripheral neuropathy, subsequent malignancies). Most previous research has been narrowly focused, investigating variation in candidate genes and pathways such as drug metabolism, DNA damage and repair, and inflammation. Few

SUBMITTER: Morton LM 

PROVIDER: S-EPMC6415750 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature