The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update.

ABSTRACT:

Purpose of review

The environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the Young (TEDDY) Study follows from birth 8676 children with T1D risk HLA-DR-DQ genotypes in the USA, Finland, Germany, and Sweden. Most study participants (89%) have no first-degree relative with T1D. The primary outcomes include the appearance of one or more persistent islet autoantibodies (islet autoimmunity, IA) and clinical T1D.

Recent findings

As of February 28, 2018, 769 children had developed IA and 310 have progressed to T1D. Secondary outcomes include celiac disease and autoimmune thyroid disease. While the follow-up continues, TEDDY has already evaluated a number of ca

SUBMITTER: Rewers M 

PROVIDER: S-EPMC6415767 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature