Protective effect of TSLP and IL-33 cytokines in ulcerative colitis.

ABSTRACT:

Purpose

Inflammatory bowel disease (IBD) primarily includes ulcerative colitis (UC) and Crohn's disease (CD). Thymic stromal lymphopoietin (TSLP) is a cytokine produced by intestinal epithelial cells (IECs) with immunomodulatory properties that plays an important role in the development of regulatory T cell (Treg) responses and tolerance in the gut. On the other hand, IL-33 has been considered as a cytokine with two different properties, inflammatory and anti-inflammatory functions, the latter may play a protective role against chronic intestinal inflammation. In the present study, we investigated the relative gene expression levels of TSLP and IL-33 molecules in ulcerative colitis.

Methods

Patients with clinical symptoms of colitis undergoing a routine diagnostic colonoscop

SUBMITTER: Tahaghoghi-Hajghorbani S 

PROVIDER: S-EPMC6416230 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature