T-cell senescence contributes to abnormal glucose homeostasis in humans and mice.

ABSTRACT: Chronic inflammation is a driving force for the development of metabolic disease including diabetes and obesity. However, the functional characteristics of T-cell senescence in the abnormal glucose homeostasis are not fully understood. We studied the patients visiting a hospital for routine health check-ups, who were divided into two groups: normal controls and people with prediabetes. Gene expression profiling of peripheral blood mononuclear cells from normal controls and patients with type 2 diabetes was undertaken using microarray analysis. We also investigated the immunometabolic characteristics of peripheral and hepatic senescent T cells in the normal subjects and patients with prediabetes. Moreover, murine senescent T cells were tested functionally in the liver of normal or mice with

SUBMITTER: Yi HS 

PROVIDER: S-EPMC6416326 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature