Odor mixtures of opposing valence unveil inter-glomerular crosstalk in the Drosophila antennal lobe.

ABSTRACT: Evaluating odor blends in sensory processing is a crucial step for signal recognition and execution of behavioral decisions. Using behavioral assays and 2-photon imaging, we have characterized the neural and behavioral correlates of mixture perception in the olfactory system of Drosophila. Mixtures of odors with opposing valences elicit strong inhibition in certain attractant-responsive input channels. This inhibition correlates with reduced behavioral attraction. We demonstrate that defined subsets of GABAergic interneurons provide the neuronal substrate of this computation at pre- and postsynaptic loci via GABA_B- and GABA_A receptors, respectively. Intriguingly, manipulation of single input channels by silencing and optogenetic activation unveils a glomerulus-specifi

SUBMITTER: Mohamed AAM 

PROVIDER: S-EPMC6416470 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature