The Impact of Reducing Antibiotics on the Transmission of Multidrug-Resistant Organisms.

ABSTRACT: OBJECTIVE Antibiotic resistance is a major threat to public health. Resistance is largely driven by antibiotic usage, which in many cases is unnecessary and can be improved. The impact of decreasing overall antibiotic usage on resistance is unknown and difficult to assess using standard study designs. The objective of this study was to explore the potential impact of reducing antibiotic usage on the transmission of multidrug-resistant organisms (MDROs). DESIGN We used agent-based modeling to simulate interactions between patients and healthcare workers (HCWs) using model inputs informed by the literature. We modeled the effect of antibiotic usage as (1) a microbiome effect, for which antibiotic usage decreases competing bacteria and increases the MDRO transmission probability between patie

SUBMITTER: Barnes SL 

PROVIDER: S-EPMC6416785 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature