Sample size calculations for model validation in linear regression analysis.

ABSTRACT:

Background

Linear regression analysis is a widely used statistical technique in practical applications. For planning and appraising validation studies of simple linear regression, an approximate sample size formula has been proposed for the joint test of intercept and slope coefficients.

Methods

The purpose of this article is to reveal the potential drawback of the existing approximation and to provide an alternative and exact solution of power and sample size calculations for model validation in linear regression analysis.

Results

A fetal weight example is included to illustrate the underlying discrepancy between the exact and approximate methods. Moreover, extensive numerical assessments were conducted to examine the relative performance of the two distinct procedur

SUBMITTER: Jan SL 

PROVIDER: S-EPMC6416874 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature