Genetic regulation of methylation in human endometrium and blood and gene targets for reproductive diseases.

ABSTRACT:

Background

Major challenges in understanding the functional consequences of genetic risk factors for human disease are which tissues and cell types are affected and the limited availability of suitable tissue. The aim of this study was to evaluate tissue-specific genotype-epigenetic characteristics in DNA samples from both endometrium and blood collected from women at different stages of the menstrual cycle and relate results to genetic risk factors for reproductive traits and diseases.

Results

We analysed DNA methylation (DNAm) data from endometrium and blood samples from 66 European women. Methylation profiles were compared between stages of the menstrual cycle, and changes in methylation overlaid with changes in transcription and genotypes. We observed large changes in me

SUBMITTER: Mortlock S 

PROVIDER: S-EPMC6416889 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature