Roadmap of DNA methylation in breast cancer identifies novel prognostic biomarkers.

ABSTRACT:

Background

Breast cancer is a highly heterogeneous disease resulting in diverse clinical behaviours and therapeutic responses. DNA methylation is a major epigenetic alteration that is commonly perturbed in cancers. The aim of this study is to characterize the relationship between DNA methylation and aberrant gene expression in breast cancer.

Methods

We analysed DNA methylation and gene expression profiles from breast cancer tissue and matched normal tissue in The Cancer Genome Atlas (TCGA). Genome-wide differential methylation analysis and methylation-gene expression correlation was performed. Gene expression changes were subsequently validated in the METABRIC dataset. The Oncoscore tool was used to identify genes that had previously been associated with cancer in the litera

SUBMITTER: de Almeida BP 

PROVIDER: S-EPMC6416975 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature