Peripheral infusion of human umbilical cord mesenchymal stem cells rescues acute liver failure lethality in monkeys.

ABSTRACT:

Background

Acute liver failure (ALF) is a complicated clinical syndrome associated with high mortality, with liver transplantation as the only treatment option. Treatment of mesenchymal stem cells has shown a potential therapeutic option for acute liver failure. However, the lack of random clinical trials and large non-human primate studies makes it necessary to assess the efficacy and safety in the clinic.

Methods

We treated the monkeys with peripheral delivery of human umbilical MSCs (hUC-MSCs) and investigated the role of hUC-MSCs in modulating the progress of acute liver failure.

Results

The use of early peripheral infusion of human umbilical cord MSC infusion did not improve liver regeneration or modulate adaptive immunity. However, it significantly suppressed th

SUBMITTER: Guo G 

PROVIDER: S-EPMC6417089 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature