Effect of linoleic acid on ischemic heart disease and its risk factors: a Mendelian randomization study.

ABSTRACT:

Background

The role of n-6 polyunsaturated fatty acids (PUFAs) in ischemic heart disease (IHD) is controversial, and dietary guidelines vary. Observationally, lower saturated fat intake and higher intake of vegetable oils rich in linoleic acid (LA), the main n-6 PUFA, is associated with lower IHD and diabetes; however, randomized controlled trials have not fully corroborated these benefits. We assessed how genetically predicted LA affected IHD and its risk factors, including diabetes, lipids, and blood pressure. We also assessed the role of LA in reticulocyte count, the red blood cell precursor, which has recently been identified as a possible causal factor in IHD.

Methods

Two-sample instrumental variable analysis with genetic instruments, i.e., Mendelian randomization, was

SUBMITTER: Zhao JV 

PROVIDER: S-EPMC6417131 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature