A multi-parent recombinant inbred line population of C. elegans allows identification of novel QTLs for complex life history traits.

ABSTRACT:

Background

The nematode Caenorhabditis elegans has been extensively used to explore the relationships between complex traits, genotypes, and environments. Complex traits can vary across different genotypes of a species, and the genetic regulators of trait variation can be mapped on the genome using quantitative trait locus (QTL) analysis of recombinant inbred lines (RILs) derived from genetically and phenotypically divergent parents. Most RILs have been derived from crossing two parents from globally distant locations. However, the genetic diversity between local C. elegans populations can be as diverse as between global populations and could thus provide means of identifying genetic variation associated with complex traits relevant on a broader scale.

Results

To investigate

SUBMITTER: Snoek BL 

PROVIDER: S-EPMC6417139 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature