First dengue virus seroprevalence study on Madeira Island after the 2012 outbreak indicates unreported dengue circulation.

ABSTRACT:

Background

In 2012, the first dengue virus outbreak was reported on the Portuguese island of Madeira with 1080 confirmed cases. Dengue virus of serotype 1 (DENV-1), probably imported from Venezuela, caused this outbreak with autochthonous transmission by invasive Aedes aegypti mosquitoes.

Results

We investigated the seroprevalence among the population on Madeira Island four years after the outbreak. Study participants (n = 358), representative of the island population regarding their age and gender, were enrolled in 2012 in a cross-sectional study. Dengue antibodies were detected with an in-house enzyme-linked immunosorbent assay (ELISA) using the dimer of domain III (ED3) of the DENV-1 envelope protein as well as commercial Panbio indirect and capture IgG ELISAs. Positive E

SUBMITTER: Auerswald H 

PROVIDER: S-EPMC6417143 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature