FTO haplotyping underlines high obesity risk for European populations.

ABSTRACT:

Background

Fat mass and obesity-associated (FTO) gene has been under close investigation since the discovery of its high impact on the obesity status in 2007 by a range of publications. Recent report on its implication in adipocytes underscored its molecular and functional mechanics in pathology. Still, the population specific features of the locus structure have not been approached in detail.

Methods

We analyzed the population specific haplotype profiles of FTO genomic locus identified by Genome Wide Association Studies (GWAS) for the high obesity risk by examining eighteen 1000G populations from 4 continental groups. The GWAS SNPs cluster is located in the FTO gene intron 1 spanning around 70 kb.

Results

We reconstructed the ancestral state of the locus, which compr

SUBMITTER: Babenko V 

PROVIDER: S-EPMC6417164 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature