Metagenomic analysis of microbe-mediated vitamin metabolism in the human gut microbiome.

ABSTRACT:

Background

Human gut microbial communities have been known to produce vitamins, which are subsequently absorbed by the host in the large intestine. However, the relationship between species with vitamin pathway associated functional features or their gene abundance in different states of health and disease is lacking. Here, we analyzed shotgun fecal metagenomes of individuals from four different countries for genes that are involved in vitamin biosynthetic pathways and transport mechanisms and corresponding species' abundance.

Results

We found that the prevalence of these genes were found to be distributed across the dominant phyla of gut species. The number of positive correlations were high between species harboring genes related to vitamin biosynthetic pathways and transp

SUBMITTER: Das P 

PROVIDER: S-EPMC6417177 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature