Uptake and distribution of carboxylated quantum dots in human mesenchymal stem cells: cell growing density matters.

ABSTRACT:

Background

Human mesenchymal stem cells (MSCs) have drawn much attention in the field of regenerative medicine for their immunomodulatory and anti-inflammatory effects. MSCs possess specific tumor-oriented migration and incorporation highlighting the potential for MSCs to be used as an ideal carrier for anticancer agents. Bone marrow is the main source of MSCs for clinical applications. MSCs tracking in vivo is a critical component of the safety and efficacy evaluation of therapeutic cell products; therefore, cells must be labeled with contrast agents to enable visualization of the MSCs migration in vivo. Due to their unique properties, quantum dots (QDs) are emerging as optimal tools in long-term MSC optical imaging applications. The aim of this study was to investigate the uptake

SUBMITTER: Kundrotas G 

PROVIDER: S-EPMC6417192 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature