Prebiotic supplementation in frail older people affects specific gut microbiota taxa but not global diversity.

ABSTRACT:

Background

There are complex interactions between aging, frailty, diet, and the gut microbiota; modulation of the gut microbiota by diet could lead to healthier aging. The purpose of this study was to test the effect of diets differing in sugar, fat, and fiber content upon the gut microbiota of mice humanized with microbiota from healthy or frail older people. We also performed a 6-month dietary fiber supplementation in three human cohorts representing three distinct life-stages.

Methods

Mice were colonized with human microbiota and then underwent an 8-week dietary intervention with either a high-fiber/low-fat diet typical of elderly community dwellers or a low-fiber/high-fat diet typical of long-stay residential care subjects. A cross-over design was used where the diets we

SUBMITTER: Tran TTT 

PROVIDER: S-EPMC6417215 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature