Organ system network analysis and biological stability in critically ill patients.

ABSTRACT:

Background

Continuous coordination among organ systems is necessary to maintain biological stability in humans. Organ system network analysis in addition to organ-oriented medicine is expected to improve patient outcomes. However, organ system networks remain beyond clinical application with little evidence for their importance on homeostatic mechanisms. This proof-of-concept study examined the impact of organ system networks on systemic stability in severely ill patients.

Methods

Patients admitted to the intensive care unit of the University of Tokyo Hospital with one representative variable reflecting the condition of each of the respiratory, cardiovascular, renal, hepatic, coagulation, and inflammatory systems were enrolled. Relationships among the condition of individual

SUBMITTER: Asada T 

PROVIDER: S-EPMC6417231 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature