Growth hormone acts along the PPARγ-FSP27 axis to stimulate lipolysis in human adipocytes.

ABSTRACT: The lipolytic effects of growth hormone (GH) have been known for half a century and play an important physiological role for substrate metabolism during fasting. In addition, sustained GH-induced lipolysis is causally linked to insulin resistance. However, the underlying molecular mechanisms remain elusive. In the present study, we obtained experimental data in human subjects and used human adipose-derived stromal vascular cells (hADSCs) as a model system to elucidate GH-triggered molecular signaling that stimulates adipose tissue lipolysis and insulin resistance in human adipocytes. We discovered that GH downregulates the expression of fat-specific protein (FSP27), a negative regulator of lipolysis, by impairing the transcriptional ability of the master transcriptional regulator, peroxiso

SUBMITTER: Sharma VM 

PROVIDER: S-EPMC6417689 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature