High-dose rifampicin in tuberculosis: Experiences from a Dutch tuberculosis centre.

ABSTRACT:

Background

Recent evidence suggests that higher rifampicin doses may improve tuberculosis (TB) treatment outcome.

Methods

In this observational cohort study we evaluated all TB patients who were treated with high-dose rifampicin (> 10 mg/kg daily) in our reference centre, from January 2008 to May 2018. Indications, achieved plasma rifampicin exposures, safety and tolerability were evaluated.

Results

Eighty-eight patients were included. The main indications were low plasma concentrations (64.7%) and severe illness (29.5%), including central nervous system TB. Adjusted rifampicin dosages ranged from 900 mg to a maximum of 2400 mg (corresponding to 32 mg/kg) per day. Patients with severe illness received high-dose rifampicin immediately, the others had a higher dosage gu

SUBMITTER: Seijger C 

PROVIDER: S-EPMC6417786 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature