Type 2 Diabetes and Hypertension.

ABSTRACT:

Rationale

In observational studies, type 2 diabetes mellitus (T2D) has been associated with an increased risk of hypertension, and vice versa; however, the causality between these conditions remains to be determined.

Objectives

This population-based prospective cohort study sought to investigate the bidirectional causal relations of T2D with hypertension, systolic and diastolic blood pressure (BP) using Mendelian randomization (MR) analysis.

Methods and results

After exclusion of participants free of a history of heart failure, cardiovascular disease, cardiac procedures, and non-T2D diabetes mellitus, a total of 318 664 unrelated individuals with qualified genotyping data of European descent aged 37 to 73 from UK Biobank were included. The genetically instrumented T2D

SUBMITTER: Sun D 

PROVIDER: S-EPMC6417940 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature