Camouflaging Nanoparticles for Ratiometric Delivery of Therapeutic Combinations.

ABSTRACT: Combination therapy is a common clinical practice in the management of malignancies. Synergistic therapeutic outcomes are achieved only when tumor cells are exposed to drugs in an optimal ratio and sequence; therefore, carriers coencapsulating multiple drugs are widely pursued for their coordinated delivery. However, it is challenging to coload drugs with different physicochemical properties in a single carrier with specific ratios. It is not even beneficial to load them in one carrier if they need to be released at different times. We propose to load drugs into chemically compatible carriers separately, equalize different carriers by a simple, rapid, and versatile camouflage technique based on natural polyphenol tannic acid (TA), and administer them in desirable ratios and sequences. To d

SUBMITTER: Meng F 

PROVIDER: S-EPMC6417971 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature