Determining Antigen Specificity of Human Islet Infiltrating T Cells in Type 1 Diabetes.

ABSTRACT: Type 1 diabetes, the immune mediated form of diabetes, represents a prototypical organ specific autoimmune disease in that insulin producing pancreatic islets are specifically targeted by T cells. The disease is now predictable in humans with the measurement of type 1 diabetes associated autoantibodies (islet autoantibodies) in the peripheral blood which are directed against insulin and beta cell proteins. With an increasing incidence of disease, especially in young children, large well-controlled clinical prevention trials using antigen specific immunotherapy have been completed but with limited clinical benefit. To improve outcomes, it is critical to understand the antigen and T cell receptor repertoires of those cells that infiltrate the target organ, pancreatic islets, in human type 1

SUBMITTER: Nakayama M 

PROVIDER: S-EPMC6418007 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature