Genetic and epigenetic architecture of paternal origin contribute to gestation length in cattle.
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ABSTRACT:
SUBMITTER: Fang L
PROVIDER: S-EPMC6418173 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Genetic and epigenetic architecture of paternal origin contribute to gestation length in cattle.
Fang Lingzhao L Jiang Jicai J Li Bingjie B Zhou Yang Y Freebern Ellen E Vanraden Paul M PM Cole John B JB Liu George E GE Ma Li L
Communications biology 20190314
The length of gestation can affect offspring health and performance. Both maternal and fetal effects contribute to gestation length; however, paternal contributions to gestation length remain elusive. Using genome-wide association study (GWAS) in 27,214 Holstein bulls with millions of gestation records, here we identify nine paternal genomic loci associated with cattle gestation length. We demonstrate that these GWAS signals are enriched in pathways relevant to embryonic development, and in diff ...[more]
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