Brain sugar consumption during neuronal activation detected by CEST functional MRI at ultra-high magnetic fields.

ABSTRACT: Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) indirectly measures brain activity based on neurovascular coupling, a reporter that limits both the spatial and temporal resolution of the technique as well as the cellular and metabolic specificity. Emerging methods using functional spectroscopy (fMRS) and diffusion-weighted fMRI suggest that metabolic and structural modifications are also taking place in the activated cells. This paper explores an alternative metabolic imaging approach based on Chemical Exchange Saturation Transfer (CEST) to assess potential metabolic changes induced by neuronal stimulation in rat brains at 17.2 T. An optimized CEST-fMRI data acquisition and processing protocol was developed and used to experimentally assess the feasibi

SUBMITTER: Roussel T 

PROVIDER: S-EPMC6418181 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature