An analysis of benign human prostate offers insights into the mechanism of apocrine secretion and the origin of prostasomes.

ABSTRACT: The structure and function of normal human prostate is still not fully understood. Herein, we concentrate on the different cell types present in normal prostate, describing some previously unreported types and provide evidence that prostasomes are primarily produced by apocrine secretion. Patients (n = 10) undergoing TURP were prospectively consented based on their having a low risk of harbouring CaP. Scanning electron microscopy and transmission electron microscopy was used to characterise cell types and modes of secretion. Zinc levels were determined using Inductively Coupled Plasma Mass Spectrometry. Although merocrine secretory cells were noted, the majority of secretory cells appear to be apocrine; for the first time, we clearly show high-resolution images of the stages of aposome sec

SUBMITTER: Fullwood NJ 

PROVIDER: S-EPMC6418221 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature