Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations.

ABSTRACT: Mitochondria are organelles that govern energy supply and control cell death. Mitochondria also express bacterial features, such as the presence of inner membrane cardiolipin and a circular genome rich in hypomethylated CpG motifs. While mitochondrial extrusion by damaged organs or activated cells is thought to trigger innate immunity, it is unclear whether extracellular mitochondria also stimulate an adaptive immune response. We describe the development of novel assays to detect autoantibodies specific to two distinct components of the mitochondrion: the mitochondrial outer membrane and mitochondrial DNA. Antibodies to these two mitochondrial constituents were increased in both human and murine systemic lupus erythematosus (SLE), compared to controls, and were present at higher levels tha

SUBMITTER: Becker Y 

PROVIDER: S-EPMC6418244 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature