The promising role of PAX1 (aliases: HUP48, OFC2) gene methylation in cancer screening.

ABSTRACT:

Background

Paired-box gene 1 (PAX1), a member of the PAX family, plays a role in pattern formation during embryogenesis, and might be essential for development of the vertebral column.

Methods

PAX1 is silenced by methylation in several cancers and is considered a tumor suppressor gene. Our previous studies reported PAX1 as hypermethylated in cervical cancer tissues, thereby suggesting it as a potential screening marker. Recently, an increasing number of studies have confirmed PAX1 methylation as a promising biomarker in cervical cancer based on its excellent discriminatory ability between high-grade cervical lesions and normal tissues, resulting in a reduced necessity for referral for colposcopy and biopsy. Additionally, PAX1 is also hypermethylated in other tumors, includin

SUBMITTER: Fang C 

PROVIDER: S-EPMC6418350 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature