Genetic analysis of the relation of telomere length-related gene (RTEL1) and coronary heart disease risk.

ABSTRACT:

Background

Regulator of telomere elongation helicase 1 (RTEL1), a telomere length-related gene, is closely linked to cancer and age-related diseases. The aim of this study was to investigate the association between genetic polymorphisms in the RTEL1 gene and coronary heart disease (CHD) risk.

Methods

In this case-control study, which includes samples from 596 CHD patients and 603 healthy controls, five SNPs in RTEL1 were selected. The genotypes were studied using the Agena MassARRAY platform, and the statistical analyses were performed using the chi-square and Fisher's exact tests, genetic model analysis, and haplotype analysis.

Results

In the allele model, using the chi-square test, we found that the patients with the "G" allele of rs6010620 and the "C" allele of rs4

SUBMITTER: Lu S 

PROVIDER: S-EPMC6418357 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature