Association between the IL1R2 rs2072472 polymorphism and high-altitude pulmonary edema risk.

ABSTRACT:

Aim

High-altitude pulmonary edema (HAPE), as a multifactorial disease, is caused by stress failure and involves both environmental and genetic factors. Study shows that IL-1 receptors can selectively decrease the oxygen arterial hypertension and influence the blood coagulation. So we evaluated whether genetic polymorphisms in IL1R1 and 1L1R2 genes are associated with the risk of HAPE in Chinese Han population.

Methods

Ten susceptible SNPs in the IL1R1 and IL1R2 genes were genotyped among 265 HAPE cases and 303 controls using the Agena MassARRAY platform. The associations of the SNP frequencies with HAPE were analyzed by chi-square (χ² ) test/Fisher's test. The genetic models were used to evaluate associations.

Results

In the allele model, we found that rs20

SUBMITTER: Jin T 

PROVIDER: S-EPMC6418374 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature