Lifespan Trajectories of White Matter Changes in Rhesus Monkeys.

ABSTRACT: Progress in neurodevelopmental brain research has been achieved through the use of animal models. Such models not only help understanding biological changes that govern brain development, maturation and aging, but are also essential for identifying possible mechanisms of neurodevelopmental and age-related chronic disorders, and to evaluate possible interventions with potential relevance to human disease. Genetic relationship of rhesus monkeys to humans makes those animals a great candidate for such models. With the typical lifespan of 25 years, they undergo cognitive maturation and aging that is similar to this observed in humans. Quantitative structural neuroimaging has been proposed as one of the candidate in vivo biomarkers for tracking white matter brain maturation and aging. While lif

SUBMITTER: Kubicki M 

PROVIDER: S-EPMC6418383 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature