Cocaine Decreases Spontaneous Neuronal Activity and Increases Low-Frequency Neuronal and Hemodynamic Cortical Oscillations.

ABSTRACT: Low-frequency oscillations (LFOs) in hemodynamics assessed by fMRI reflect synchronized neuronal activities and are the basis for mapping brain function and its disruption by drugs and disease. Here we assess if cocaine disrupts coupling between neuronal and vascular LFOs by simultaneously measuring cortical field potentials (FP) and cerebral blood flow (CBF) regarding their LFOs (0-1 Hz) spectral bandwidths in the somatosensory cortex of naïve and chronic cocaine-exposed rats at baseline and during cocaine intoxication. While across all conditions the dominant oscillation frequencies for FP and CBF LFOs were ~0.1 Hz, the bandwidth of FP LFOs was about 4.8 ± 0.67 times broader than that of CBF LFOs. Acute cocaine depressed high-frequency FP events but increased the relative intensity of ne

SUBMITTER: Chen W 

PROVIDER: S-EPMC6418395 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature