Vitamin K for reversal of excessive vitamin K antagonist anticoagulation: a systematic review and meta-analysis.

ABSTRACT: Patients receiving vitamin K antagonists (VKAs) with an international normalized ratio (INR) between 4.5 and 10 are at increased risk of bleeding. We systematically reviewed the literature to evaluate the effectiveness and safety of administering vitamin K in patients receiving VKA therapy with INR between 4.5 and 10 and without bleeding. Medline, Embase, and Cochrane databases were searched for relevant randomized controlled trials in April 2018. Search strategy included terms vitamin K administration and VKA-related terms. Reference lists of relevant studies were reviewed, and experts in the field were contacted for relevant papers. Two investigators independently screened and collected data. Risk ratios (RRs) were calculated, and certainty of the evidence was assessed using Grading of R

SUBMITTER: Khatib R 

PROVIDER: S-EPMC6418499 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature