Presenting Precision Glycomacromolecules on Gold Nanoparticles for Increased Lectin Binding.

ABSTRACT: Glyco-functionalized gold nanoparticles have great potential as biosensors and as inhibitors due to their increased binding to carbohydrate-recognizing receptors such as the lectins. Here we apply previously developed solid phase polymer synthesis to obtain a series of precision glycomacromolecules that allows for straightforward variation of their chemical structure as well as functionalization of gold nanoparticles by ligand exchange. A novel building block is introduced allowing for the change of spacer building blocks within the macromolecular scaffold going from an ethylene glycol unit to an aliphatic spacer. Furthermore, the valency and overall length of the glycomacromolecule is varied. All glyco-functionalized gold nanoparticles show high degree of functionalization along with high

SUBMITTER: Boden S 

PROVIDER: S-EPMC6418785 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature