Synthesis and Nanoprecipitation of HEMA-CL_n Based Polymers for the Production of Biodegradable Nanoparticles.

ABSTRACT: The control over the size distribution and stability of polymeric nanoparticles (NPs) is crucial in many of their applications, especially in the biomedical field. These characteristics are typically influenced by the production method and the nature of the starting material. To investigate these aspects, the controlled radical polymerization of functionalized methacrylates constituted by 2-hydroxyethyl methacrylate (HEMA) functionalized with a controlled number of ε-caprolactone (CL) units (HEMA-CL_n), was carried out via reversible addition⁻fragmentation chain transfer polymerization (RAFT) in solution. The living reaction allows for good control over the molar mass of the final polymer with a low molar mass dispersity. The obtained polymer solutions were nanoprecipitated in or

SUBMITTER: Gatti S 

PROVIDER: S-EPMC6418799 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature