Constraining Polymers into β-Turns: Miscibility and Phase Segregation Effects in Lipid Monolayers.

ABSTRACT: Abstract: Investigation of model biomembranes and their interactions with natural or synthetic macromolecules are of great interest to design membrane systems with specific properties such as drug-delivery. Here we study the behavior of amphiphilic β-turn mimetic polymer conjugates at the air⁻water interface and their interactions with lipid model membranes. For this endeavor we synthesized two different types of conjugates containing either hydrophobic polyisobutylene (PIB, M_n = 5000 g·mol^-1) or helical poly(n-hexyl isocyanate) (PHIC, M_n = 4000 g·mol^-1), both polymers being immiscible, whereas polyisobutylene as a hydrophobic polymer can incorporate into lipid membranes. The conjugates were investigated using L

SUBMITTER: Deike S 

PROVIDER: S-EPMC6418963 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature