The oxytocin receptor gene predicts brain activity during an emotion recognition task in autism.

ABSTRACT:

Background

Autism is a highly varied and heritable neurodevelopmental condition, and common variants explain approximately 50% of the genetic variance of autism. One of the genes implicated in autism is the oxytocin receptor (OXTR). The current study combined genetic and brain imaging (fMRI) data to examine the moderating effect of genotype on the association between diagnosis and brain activity in response to a test of cognitive empathy.

Methods

Participants were adolescents (mean age = 14.7 ± 1.7) who were genotyped for single nucleotide polymorphisms (SNPs) within the OXTR and underwent functional brain imaging while completing the adolescent version of the 'Reading the Mind in the Eyes' Test (Eyes Test).

Results

Two (rs2254298, rs53576) of the five <

SUBMITTER: Uzefovsky F 

PROVIDER: S-EPMC6419364 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature