The effects and safety of vasopressin receptor agonists in patients with septic shock: a meta-analysis and trial sequential analysis.

ABSTRACT:

Background

The aim of this study was to evaluate the effects and safety of vasopressin receptor agonists in patients with septic shock.

Methods

PubMed, EMBASE, and Cochrane library were searched for randomized controlled trials evaluating the effects of vasopressin receptor agonists in septic shock patients. Two reviewers performed literature selection, data extraction, and quality evaluation independently. The primary outcome was mortality. And secondary outcomes included intensive care unit (ICU) length of stay, duration of mechanical ventilation, and incidence of adverse events. In addition, a trial sequential analysis (TSA) was performed.

Results

Twenty studies were eligible for meta-analysis. The results showed vasopressin receptor agonists use was associated wit

SUBMITTER: Jiang L 

PROVIDER: S-EPMC6419432 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature