Optimal respiratory-gated [¹⁸F]FDG PET/CT significantly impacts the quantification of metabolic parameters and their correlation with overall survival in patients with pancreatic ductal adenocarcinoma.

ABSTRACT:

Purpose

Metabolic parameters are increasingly being used to characterize tumors. Motion artifacts due to patient respiration introduce uncertainties in quantification of metabolic parameters during positron emission tomography (PET) image acquisition. The present study investigates the impact of amplitude-based optimal respiratory gating (ORG) on quantification of PET-derived image features in patients with pancreatic ductal adenocarcinoma (PDAC), in correlation with overall survival (OS).

Methods

Sixty-nine patients with histologically proven primary PDAC underwent 2'-deoxy-2'-[¹⁸F]fluoroglucose ([¹⁸F]FDG) PET/CT imaging during diagnostic work-up. Standard image acquisition and reconstruction was performed in accordance with the EANM guidelines and ORG

SUBMITTER: Smeets EMM 

PROVIDER: S-EPMC6419652 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature