Risk Factors for Poststroke Cognitive Decline: The REGARDS Study (Reasons for Geographic and Racial Differences in Stroke).

ABSTRACT:

Background and purpose

Poststroke cognitive decline causes disability. Risk factors for poststroke cognitive decline independent of survivors' prestroke cognitive trajectories are uncertain.

Methods

Among 22 875 participants aged ≥45 years without baseline cognitive impairment from the REGARDS cohort (Reasons for Geographic and Racial Differences in Stroke), enrolled from 2003 to 2007 and followed through September 2015, we measured the effect of incident stroke (n=694) on changes in cognitive functions and cognitive impairment (Six-Item Screener score <5) and tested whether patient factors modified the effect. Median follow-up was 8.2 years.

Results

Incident stroke was associated with acute declines in global cognition, new learning, verbal memory, and executive func

SUBMITTER: Levine DA 

PROVIDER: S-EPMC6419761 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature