Characterizing human genomic coevolution in locus-gene regulatory interactions.

ABSTRACT:

Background

Coevolution has been used to identify and predict interactions and functional relationships between proteins of many different organisms including humans. Current efforts in annotating the human genome increasingly show that non-coding DNA sequence has important functional and regulatory interactions. Furthermore, regulatory elements do not necessarily reside in close proximity of the coding region for their target genes.

Results

We characterize coevolution as it appears in locus-gene interactions in the human genome, focusing on expression Quantitative Trait - Locus (eQTL) interactions. Our results show that in these interactions the conservation status of the loci is predictive of the conservation status of their target genes. Furthermore, comparing the phylogen

SUBMITTER: Savel D 

PROVIDER: S-EPMC6419833 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature