Dot2dot: accurate whole-genome tandem repeats discovery.

ABSTRACT:

Motivation

Large-scale sequencing projects have confirmed the hypothesis that eukaryotic DNA is rich in repetitions whose functional role needs to be elucidated. In particular, tandem repeats (TRs) (i.e. short, almost identical sequences that lie adjacent to each other) have been associated to many cellular processes and, indeed, are also involved in several genetic disorders. The need of comprehensive lists of TRs for association studies and the absence of a computational model able to capture their variability have revived research on discovery algorithms.

Results

Building upon the idea that sequence similarities can be easily displayed using graphical methods, we formalized the structure that TRs induce in dot-plot matrices where a sequence is compared with itself. Levera

SUBMITTER: Genovese LM 

PROVIDER: S-EPMC6419916 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature