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Hollow nanoreactors for Pd-catalyzed Suzuki-Miyaura coupling and O-propargyl cleavage reactions in bio-relevant aqueous media.

ABSTRACT: We describe the fabrication of hollow microspheres consisting of mesoporous silica nanoshells decorated with an inner layer of palladium nanoparticles and their use as Pd-nanoreactors in aqueous media. These palladium-equipped capsules can be used to promote the uncaging of propargyl-protected phenols, as well as Suzuki-Miyaura cross-coupling, in water and at physiologically compatible temperatures. Importantly, the depropargylation reaction can be accomplished in a bioorthogonal manner in the presence of relatively high concentrations of biomolecular components and even in the presence of mammalian cells.

SUBMITTER: Destito P

PROVIDER: S-EPMC6419927 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Hollow nanoreactors for Pd-catalyzed Suzuki-Miyaura coupling and <i>O</i>-propargyl cleavage reactions in bio-relevant aqueous media.

Destito Paolo P Sousa-Castillo Ana A Couceiro José R JR López Fernando F Correa-Duarte Miguel A MA Mascareñas José L JL

Chemical science 20181226 9

We describe the fabrication of hollow microspheres consisting of mesoporous silica nanoshells decorated with an inner layer of palladium nanoparticles and their use as Pd-nanoreactors in aqueous media. These palladium-equipped capsules can be used to promote the uncaging of propargyl-protected phenols, as well as Suzuki-Miyaura cross-coupling, in water and at physiologically compatible temperatures. Importantly, the depropargylation reaction can be accomplished in a bioorthogonal manner in the p ...[more]

PMID: 30996975

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