RUPEE: A fast and accurate purely geometric protein structure search.

ABSTRACT: Given the close relationship between protein structure and function, protein structure searches have long played an established role in bioinformatics. Despite their maturity, existing protein structure searches either use simplifying assumptions or compromise between fast response times and quality of results. These limitations can prevent the easy and efficient exploration of relationships between protein structures, which is the norm in other areas of inquiry. To address these limitations we have developed RUPEE, a fast and accurate purely geometric structure search combining techniques from information retrieval and big data with a novel approach to encoding sequences of torsion angles. Comparing our results to the output of mTM, SSM, and the CATHEDRAL structural scan, it is clear that

SUBMITTER: Ayoub R 

PROVIDER: S-EPMC6420038 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature