Spatially structured cell populations process multiple sensory signals in parallel in intact vascular endothelium.

ABSTRACT: Blood flow, blood clotting, angiogenesis, vascular permeability, and vascular remodeling are each controlled by a large number of variable, noisy, and interacting chemical inputs to the vascular endothelium. The endothelium processes the entirety of the chemical composition to which the cardiovascular system is exposed, carrying out sophisticated computations that determine physiological output. Processing this enormous quantity of information is a major challenge facing the endothelium. We analyzed the responses of hundreds of endothelial cells to carbachol (CCh) and adenosine triphosphate (ATP) and found that the endothelium segregates the responses to these two distinct components of the chemical environment into separate streams of complementary information that are processed in parall

SUBMITTER: Lee MD 

PROVIDER: S-EPMC6420068 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature