Stability and Roughness of Interfaces in Mechanically Regulated Tissues.

ABSTRACT: Cell division and death can be regulated by the mechanical forces within a tissue. We study the consequences for the stability and roughness of a propagating interface by analyzing a model of mechanically regulated tissue growth in the regime of small driving forces. For an interface driven by homeostatic pressure imbalance or leader-cell motility, long and intermediate-wavelength instabilities arise, depending, respectively, on an effective viscosity of cell number change, and on substrate friction. A further mechanism depends on the strength of directed motility forces acting in the bulk. We analyze the fluctuations of a stable interface subjected to cell-level stochasticity, and find that mechanical feedback can help preserve reproducibility at the tissue scale. Our results elucidate me

SUBMITTER: Williamson JJ 

PROVIDER: S-EPMC6420071 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature