Genomic insights into the 2016-2017 cholera epidemic in Yemen.

ABSTRACT: Yemen is currently experiencing, to our knowledge, the largest cholera epidemic in recent history. The first cases were declared in September 2016, and over 1.1 million cases and 2,300 deaths have since been reported¹. Here we investigate the phylogenetic relationships, pathogenesis and determinants of antimicrobial resistance by sequencing the genomes of Vibrio cholerae isolates from the epidemic in Yemen and recent isolates from neighbouring regions. These 116 genomic sequences were placed within the phylogenetic context of a global collection of 1,087 isolates of the seventh pandemic V. cholerae serogroups O1 and O139 biotype El Tor^2-4. We show that the isolates from Yemen that were collected during the two epidemiological waves of the epidemic¹-the firs

SUBMITTER: Weill FX 

PROVIDER: S-EPMC6420076 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature